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低氧诱导促红细胞生成素基因表达的机制 被引量:5

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摘要 低氧能够促进EPO基因表达。在EPO基因 3’ 端存在有低氧诱导增强子 ,而在 5’ 端旁侧序列上含有多种转录因子的结合位点。在低氧条件下 ,这些顺式调节元件与细胞核内反式作用因子特异性结合后 ,相互协调作用 ,增强EPO基因表达。
作者 陈伟 陈家佩
出处 《国外医学(生理病理科学与临床分册)》 2000年第6期467-470,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
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  • 1熊利泽,朱正华,董海龙,胡文能,候立朝,陈绍洋.Hyperbaric oxygen preconditioning induces neuroprotection against ischemia in transient not permanent middle cerebral artery occlusion rat model[J].Chinese Medical Journal,2000(9):68-71. 被引量:60
  • 2孙学军,黄俊龙,彭兆云,蒋春雷.低氧诱导因子与氧感受器[J].第二军医大学学报,2004,25(9):1023-1026. 被引量:3
  • 3陈秋生,冯霞,姜生成.牦牛肺脏高原适应性的结构研究[J].中国农业科学,2006,39(10):2107-2113. 被引量:60
  • 4金双,钟金城,陈智华,马志杰,卓娅.牦牛EPO基因部分片段的克隆测序及其分析[J].畜牧与兽医,2007,39(2):25-27. 被引量:5
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