老年性痴呆研究

Alzheimer's disease——a very refractory disease at the present time

老年性痴呆(AD)是当前最难治的疾病。因为AD是进行性神经退行性疾病,其病因不明。虽然有许多假设,但在AD,仍然有许多棘手问题要研究。虽然目前有不少治疗AD的药物,但确有一定效果的是胆碱酯酶抑制剂、安理申和哈伯因。因此,积极开发不同机理的药物是当务之急。

Alzheimer' s Disease is a refractory disease up to present day, because it is neuronal degeneration with ir-reversible process. The etiology of AD is unknown, although there are a number of hypothesis. Some work will be interest-ed and would be done for further research. On the therapy of AD, a lot of drugs were used in clinic, but it is very difficult to evaluate the effect . However, cholinesterase inhibitor like aricept and hoperane can improve the symptom, but devel-opment of new drug for AD therapy is a urgent task on the difierent targets other than cholinesterase inhibitor.