小剂量压宁定治疗陈旧性心肌梗塞合并慢性充血性心力衰竭

Effect of a small dose of urapidil on treating chronic congestive heart fallure In patients with old myocardial infarction

对96例陈旧性心肌梗塞心功能Ⅲ～Ⅳ级的病人随机分为压宁定组(A组,48例)和对照组(B组,48例)。两组均接受心力衰竭的常规治疗,A组在此基础上加用压宁定每晚15mg口服。结果显示,两组病人入选时的一般临床情况、心功能分级、彩色超声心动图测定的左室大小及左室射血分数均无显著性差异。治疗6个月后,两组NYHA心功能级别均明显降低,左室射血分数(LVEF 明显增加,左室收缩末内径(LVESV)及舒张末内径(LVEDV)缩小,A组LVESV和LVEDV缩小和LVEF的增加较B组更明显,但治疗后两组NYHA心功能分级的差异无显著性。提示小剂量压宁定口服可改善陈旧性心肌梗塞合并充血性心力衰竭病人的左心功能。

Ninetv - six old mvocardial infarction patients with severe chronic congestive heart failure were randomly di-vided into two groups: group A (urapidil group) and group 6 (control group) . Group B only got conventional therapy. Besides conventional treatment, patients in group A took 15mg urapidil per evening. Patients were followed up for6 month. The result showed that both groups had a significant improvement in NYHA class, decrease in left ventricular end - diastolic volume and end - systolic volume, and significant increase of left ventricular ejection Eraction. The increase of LVEF and decrease of LVESV and LVEDV in group A was more significant than in group B. It is concluded that a small dose of urapidil is beneficial in improving left ventricular function in OMI patients with severe chronic congestive heart failure.