结核杆菌中细胞色素P450蛋白的结构与功能研究进展

Research Progresses on Structure and Function of P450 Proteins from Mycobacterium tuberculosis

对近年来结核杆菌中P450蛋白结构与功能的研究进展进行了综述,并对其中结构已知的P450蛋白的结构特点、可能功能及作为药物靶点的研究进展进行了详细的比较与论述,对结构未知的P450蛋白则进行了功能重要性的研究和预测,探讨了P450蛋白作为药物靶点以研发新型高效抗结核药物的可能性及前景。

The recent research progresses on structure and function of P450 proteins from Mycobacterium tuberculosis were reviewed. For the structure known P450s, the structure characters, possible functions and research developments as drug targets were compared and analyzed; while for the structure unknown P450s, the functional importances were studied and predicted. The possibility and perspective of P450s in Mycobacterium tuberculosis as target for developing innovative anti-TB drugs were also discussed.