溶脲脲原体感染对大鼠睾丸Sertoli细胞FasL表达的影响

The Effect of Ureaplasma Urealyticum on the Expression of Fas Ligand on Rat Sertoli Cells

溶脲脲原体（Ｕｒｅａｐｌａｓｍａ Ｕｒｅａｌｙｔｉｃｕｍ，ＵＵ）是泌尿生殖道感染的常见病原体，可导致睾丸明显的病理损伤，且与不育有关。本文以对数生长期的ＵＵ、热灭活ＵＵ和ＵＵ上清液体外感染或作用于大鼠的Ｓｅｒｔｏｌｉ细胞，观察Ｓｅｒｔｏｌｉ细胞表面 ＦａｓＬ表达的变化。实验证明，活ＵＵ、热灭活 ＵＵ和 ＵＵ上清感染后，Ｓｅｒｔｏｌｉ细胞表面 ＦａｓＬ表达均增加，其中以活ＵＵ感染的影响最为明显。提示睾丸组织的免疫豁免与其局部的ＦａｓＬ功能性表达有关；在感染时，Ｓｅｒｔｏｌｉ细胞通过上调ＦａｓＬ的表达以维持睾丸局部免疫豁免的保护机制。

Ureaplasma Urealyticum(UU)is a common pathogen in the ureogenital tracts. It has been verified that the UU infection could lead to significant pathologic changes in testis and may be re- lated to male infertility. In this paper, we studied that the effect of UU on the expression of FasL on rat Sertoli cells. It was shown that UU infection could increase the expression of FasL on Ser- toli cells. These results suggest that the funtional expression of FasL is related to the immune privilege and has the immune regulation function on the testis.