长效避孕针醋酸甲孕酮对骨质代谢的影响

Study on the Outcome of Bone Metabolism after Using Depot Medroxyprogesterone Acetate for Contraception

本文探讨长效醋酸甲孕酮避孕针（ＤＭＰＡ）对中国妇女骨质代谢的影响。自愿使用１５０ｍｇ ＤＭＰＡ避孕者３０人为实验组；采用阴茎套避孕者３０人组成对照组。１ａ后测定两组血清雌二醇（Ｅ２）、血清碱性磷酸酶（ＡＫＰ）、尿钙／肌酐（Ｃａ／Ｃｒ）、尿羟脯氨酸／肌酐（Ｈｙｐ／Ｃｒ）及非惯用臂桡尺骨超远端骨矿含量（ＢＭＣ）、骨矿密度（ＢＭＤ）。结果显示：两组血清雌二醇、血清碱性磷酸酶、尿钙／肌酐、尿羟脯氨酸／肌酐差异无显著性（Ｐ＞０．０５），两组臂桡尺骨超远端骨矿含量、骨矿密度无显著性差异（Ｐ＞０．０５）。这说明使用 ＤＭＰＡ １ａ对中国妇女骨质代谢无影响。

To study the effect of depo-medroxyprogesterone acetate (DMPA) on bone metabolism in Chinese women,sixty volunteers were divided into the experimental group (n=30)and the control group (n=30) randomly. The experimental group accepted 150 mg DMPA for contraception for 1 year. The control group women's husbands used condom for contraception for 1 year. Blood lev- els of E2 and AKP,urine levels of Ca/Cr and Hyp/Cr were measured. BMC and BMD of ultradis- tal forearm were measured. The result shows that there was no significant differences of blood levels of E2 and AKP, urine levels of Ca/Cr and Hyp/Cr(P>0. 05) between these two groups Neither of the BMC and BMD of ultradistal forearm(P>0. 05). We conclude that there was no effect on bone metabolism after using DMPA for 1 year.