银屑病全基因组关联研究进展

Progress on Genome- wide Association Study for Psoriasis

银屑病是一种常见的多基因遗传病,其确切病因尚未明确。既往研究发现HLA-C是MHC区域内与银屑病发病高度相关的易感位点。在非MHC区域内,IL12B,IL23R和TRAF3IP2等基因与银屑病的易感性显著相关。近年来利用全基因组关联分析方法已发现许多与银屑病发病相关的易感基因或位点,为银屑病的病因探讨、发病风险预测及药物研发提供重要依据。对银屑病全基因组关联研究进一步进行Meta分析,结果发现20余个新的易感基因或位点。未来银屑病全基因组关联分析研究取得实质性突破需进行多方面努力。

Psoriasis is a common polygenic disease with unclear etiology. Previous studies have identified that both HLA-C in MHC region and ILI2B, IL23R and TRAF3IP2 in non-MHC region are strongly associated with psoriasis. In recent years, a number of susceptibility loci or genes of psoriasis have been identified by ge- nome-wide association study （GWAS）. These findings provide some important basis for elucidating its etiol- ogy and pathogenesis, predicting individual onset risk and developing new medicines for this disorder. Meta analysis of GWAS data showed over 20 new susceptibility genes or loci for psoriasis. Great efforts are re- quired to gain a breakthrough in the GWAS of psoriasis.