深部真菌相关毒力因素的研究进展

The Advance of Research in the Virulence Factors of Deep Fungi

深部真菌是一类可以引起人类条件性致病的病原体,常见的致病真菌包括念珠菌属、曲霉属、隐球菌属、青霉属、孢子丝菌属等。深部真菌能发挥其致病性与毒力因子的作用密不可分。研究发现真菌毒力因子的作用常与促进病原体与宿主细胞黏附,形态转换以逃避宿主免疫系统的攻击,分泌一些色素类化合物以保护其在环境中生存,增加病原菌对抗真菌药物的耐药性等有关。文中对几种具有代表性的深部条件致病真菌毒力因素的研究进展作一综述。

The deep fungi are opportunistic pathogenic bacteria that can cause human diseases. Commonly, pathogenic fungi include Monilia, Aspergillus, Cryptococcus, Penicillium, Sporotrichum etc. Virulence factors contribute most to the pathogenicity of the deep fungi. It has been proved that the role of fungal virulence factors usually associated with the promotion of the adhesion between pathogens and host, morphological convertion in order to evade attacks of the host immune system, production of pigment compounds to protect itself in the survival environment, increasing the resistance of antifungal and so on. We will summarize progresses of research a- bout the virulence factors of the following several typical deep fungi in this review.