猪繁殖与呼吸综合征病毒致病机理及其抗病育种研究进展

Advances in Pathogenesis and Resistance Breeding of Porcine Reproductive and Respiratory Syndrome Virus

由猪繁殖与呼吸综合征病毒(PRRSV)引起的猪繁殖与呼吸综合征(PRRS)是一种严重危害世界养猪业的传染病。研究表明PRRSV通过与HS、Sn、CD163三种受体分子互作侵入宿主细胞,通过抑制天然免疫、延迟中和抗体产生等多种途径抑制机体的免疫应答,导致病毒的持续性感染。抗病育种能提高机体的天然免疫力,现在猪的抗病育种主要采取直接选择、间接选择、转基因3种途径。作者对PRRSV致病机理及抗病育种的国内外研究现状进行了分析和综述,并提出了新的研究设想。

Porcine reproductive and respiratory syndrome （PRRS） ,caused by porcine reproductive and respiratory syndrome virus （PRRSV）,is a major infectious disease leading to the most eco- nomically loss in swine industry. Research shows that PRRSV virion invade host cells via three entry mediators （HS, Sn, CD163）. PRRSV can inhibit host immune response by inhibiting innate immunity and delaying neutralizing antibody, resulting in persistent infection. Resistance breeding can improve natural immunity, mainly by means of direct selection, indirect selection and trans- gene. In this paper, the research status of PRRSV pathogenesis and resistance breeding has been re- viewed, and the development of novel resistance approaches to PRRSV are also proposed.