低氧及低氧诱导因子-1与牙周炎

Association of hypoxia and hypoxia-inducible factor-1 with periodontitis

低氧对哺乳动物炎症性疾病的发生发展具有重要调节作用。牙周炎是人类常见的口腔慢性感染性疾病之一,其局部组织也存在低氧现象。大量研究表明,厌氧菌、牙合创伤、吸烟甚至炎症本身均能使牙周局部组织处于缺血和低氧状态,而低氧和炎症又可诱导局部细胞和组织产生适应性调节反应。其中重要的调节因子是低氧诱导因子-1(hypoxia inducible factor 1,HIF-1),可通过启动并调节多个基因的表达改变以维持低氧下细胞存活和组织中的氧稳态。本文就低氧和HIF-1在牙周炎中的作用机制、HIF-1的结构和功能调控、HIF-1对牙周组织再生修复的作用等作一综述。

Hypoxia is involved in the initiation and progression of inflammatory diseases. Periodontitis is characterized by local tissue hypoxia, resulting from anaerobic infection, occlusal trauma, smoking and even inflamma- tion itself. Adaptive responses to hypoxia are triggered in the inflamed periodontal tissues by a major transcriptional fac- tor-hypoxia inducible factor-1 （ HIF-1 ）. This review highlights the the structure and functional regulation of HIF-1, the roles of hypoxia and HIF-1 in the pathogenesis of periodontitis and in periodontal regeneration.