肺炎支原体肺炎患儿血清MCP-4、MDC及CysLTs水平变化

The levels of serum monocyte chemoattractant protein 4, macrophage derived chemokine(MDC) and cysteinyl leukotrienes(CysLTs) in children with mycoplasma pneumonia

目的探讨肺炎支原体肺炎(MPP)患儿血清单核细胞趋化蛋白-4(MCP-4)、巨噬细胞衍生趋化因子(MDC)及半胱氨酰白三烯(CysLTs)水平的变化及意义。方法选取60例MPP患儿,其中伴喘息36例(MPP喘息组)、不伴喘息24例(MPP非喘息组),非肺炎支原体感染肺炎患儿30例(NMPP组),哮喘急性发作患儿35例(哮喘组)及健康儿童25例(对照组),以ELISA法测定血清MCP-4、MDC及CysLTs水平,并进行分析。结果血清MCP-4、CysLTs和MDC水平在各组间的差异均有统计学意义(P均<0.01),且均以哮喘组患儿最高。各组间两两比较,血清MCP-4、MDC水平,除MPP非喘息组和NMPP组之间差异无统计学意义(P>0.05),其余各组间差异均有统计学意义(P均<0.05);血清CysLTs水平,除哮喘组与MPP喘息组、NMPP组与MPP非喘息组之间差异无统计学意义(P均>0.05),其余各组间的差异均有统计学意义(P均<0.05)。MPP患儿的MCP-4、MDC及CysLTs水平之间呈正相关关系。结论 MCP-4、MDC及CysLTs在MPP发病中起重要作用,也是导致MPP患儿出现喘息症状的主要原因之一。

Objective To investigate the levels of monocyte chemoattractant protein 4 （MCP-4）, macrophage derived chemokine （MDC） and cysteinyl leukotrienes （CysLTs） in serum of children with mycoplasma pneumonia （MP）. Methods Serum levels of MCP-4, MDC and CysLTs measured by enzyme linked immunosorbent assay were analyzed in 60 children with MP including 36 children with wheezing （MP wheezing group） and 24 children without wheezing （MP non-wheezing group）, 30 children with pneumonia but not infected with mycoplasma pneumonia （NMP group）, 35 children with acute asthma exacerbation （asthma group）, and 25 health children （control group）. Results Serum levels of MCP-4, CysLTs and MDC were found markedly elevated in asthma group. The serum levels of MCP-4 and MDC showed signiifcant difference between each of the groups （all P〈0.01） except that between non-wheezing group and NMP group （P〉0.05）. As for serum level of CysLTs, no signiifcant differences were found between asthma group and MP wheezing group, NMP group and MP-non-wheezing group （all P〉0.05）. The serum levels of MCP-4, MCD and CysLTs in children with MP were positively correlated with one another. Conclusions MCP-4, MDC and CysLTs play important roles in pathogenesis of MP and are the major causes of wheezing in MP.