儿童肥胖与睡眠相关基因多态性

Childhood obesity and sleep related gene polymorphisms

肥胖和睡眠障碍都可表现为群发现象,儿童肥胖可引起睡眠呼吸紊乱,同时睡眠呼吸紊乱和睡眠剥夺,也可影响能量代谢相关基因的表达,导致超重或肥胖,甚至代谢综合征的发生。文章针对肥胖相关基因多态性及其与儿童睡眠障碍的关系,综述国内外研究进展。

Obesity and sleep disorders are both familial clustering. Childhood obesity can cause sleep disordered breathing and sleep deprivation. The expression of energy metabolism related genes can also be inlfuenced by obesity, which may lead to overweight or obesity, even metabolic syndrome. In this review, the recent progress on obesity related gene polymorphism and its relationship to childhood sleep disorders is summerized.