白细胞介素16基因多态性与食管鳞癌的相关性

Association between IL-16 Polymorphisms and Risk of Esophageal Squamous Cell Carcinoma

目的探讨白细胞介素16(Interleukin-16,IL-16)基因多态性与食管鳞癌的关联。方法采用聚合酶链反应-限制性片段长度多态性方法检测IL-16基因多态性在188例健康对照组和155例食管鳞癌组中的分布,并分析其与临床特征的相关性。结果 rs11556218TG基因型在食管鳞癌组中的频率明显高于其在对照组中的频率(54.8%比42.6%,χ2=6.02,P=0.014);rs11556218G等位基因在食管鳞癌组中的频率明显高于其在对照组中的频率(32.6%比25.0%,χ2=4.80,P=0.03)。rs4778889和rs4072111两位点基因型和等位基因分布在食管鳞癌组和对照组中无明显差异(P>0.05)。结论 IL-16rs11556218多态性与食管鳞癌的发病相关。

Objective To investigate the association between IL-16 polymorphisms and risk of esophageal squamous cell carcinoma （ESCC）. Methods The IL-16 polymorphisms were genotyped in 188 healthy controls and 155 patients with ESCC using polymerase chain reaction-restriction fragment length polymorphism method. Moreover,the relation- ship between the IL-16 polymorphisms and clinical features was also analyzed. Results The frequency of rsl1556218TG genotype in patients with ESCC was significantly higher than that in healthy controls （54. 8% vs. 42.6%,）2 = 6.02, P= 0. 014）. Similarly, the frequency of rsl1556218G allele in patients with ESCC was significantly higher than that in healthy controls （32.6% vs. 25.0%,X^2=4.80,P= 0.03）. No significant association was observed between rs4778889 and rs4072111 polymorphisms and ESCC risk. Conclusion IL 16 rs11556218 polymorphism may be associated with the development of ESCC.