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视神经脊髓炎的可能生物标记物 被引量：5

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摘要 视神经脊髓炎(neuromyelitis optica,NMO)患者的血清中存在特异性抗体"NMO-IgG",即AQP4抗体其靶点为位于星形胶质细胞足突上的水通道蛋白-4(aquaporin-4,AQP4),可用于诊断NMO并与多发性硬化相鉴别。越来越多的研究表明,除AQP4抗体外,细胞因子、趋化因子、星形胶质细胞及血-脑脊液屏障损伤的标记物等在NMO的发病过程中也扮演重要角色,有可能成为NMO的生物标记物。
作者 杨芬 黄德晖 吴卫平
机构地区 解放军总医院南楼神经内科 解放军总医院神经内科
出处 《中国神经免疫学和神经病学杂志》 CAS 北大核心 2013年第6期424-426,共3页 Chinese Journal of Neuroimmunology and Neurology
关键词 视神经脊髓炎 生物标记物
分类号 R744.52 [医药卫生—神经病学与精神病学]
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参考文献17

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  • 2Lennon VA, Kryzer TJ, Pittock SJ, et al. IgG marker of op- tic spinal multiple sclerosis binds to the aquaporin-4 water channel[J]. J ExpMed, 2005, 202:473-477.
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同被引文献27

  • 1赵凡,陆文华,塔娜,焦辉,赵金,赵冉.莱姆病少见表现视神经脊髓炎1例[J].中国罕少疾病杂志,1998,5(2):49-50. 被引量：1
  • 2LENNON VA, KRYZER TJ, PIq'TOCK SJ, et al. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel [ J ]. J Exp Med, 2005,202 (4) : 473-477.
  • 3TAKANO R, MISU T, TAKAHASHI T, et al. Astroeytic damage is far more severe than demyelination in NMO: a clinical CSF biomarker study [J]. Neurology, 2010,75 (3) : 208-216.
  • 4UZAWA A, MORI M, KUWABARA S. Cytokines and chemokines in neuromyelitis optica: pathogenetic and therapeutic implications [ J ]. Brain Pathol, 2014,24 ( 1 ) : 67-73.
  • 5WINGEREHUK DM, LENNON VA, PITI'OCK SJ, et al. Revised diagnostic criteria for neuromyelitis optiea [J]. Neurology, 2006,66(10) : 1485-1489.
  • 6JARIU S, PAUL F, FRANCIOTTA D, et al. Mechanisms of disease : Aquaporin-4 antibodies in neuromyelitis potica [J].Nat Clin Pract Neurol, 2008,4(4) :202-214.
  • 7UZAWA A, MORI M, ARAI K, et at. Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6[J]. Multiple Sclerosis, 2010,16(12) : 1443-1452.
  • 8WANG KC, LEE CL, CHEN SY, et al. Distinct serum cytokine profiles in neuromyelitis optica and multiple sclerosis [J]. J Interferon Cytokine Res, 2013,33 (2) : 58-64.
  • 9CHIHARA N, ARANAMI F, SATO W, et al. Interleukin 6 signaling promotes antiaquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica[ J ]. PNAS, 2011,108 (9) : 3701-3706.
  • 10WEI J, ZHENG M, LIANG P, et al. Apolipoprotein E and its mimetic peptide suppress Thl and Thl7 responses in experimental autoimmune encephalomyelitis [J]. Neurobiol Dis, 2013,56(8) :59-65.

引证文献5

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中国神经免疫学和神经病学杂志
2013年 第6期

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