颈动脉粥样硬化与血管性痴呆的相关性分析

Association between vascular dementia and carotid artery atherosclerosis

目的探讨颈动脉粥样硬化对血管性痴呆发生、发展的影响。方法对61例血管性痴呆(VaD)患者(VaD组)及70例健康体检者(对照组)行高频超声检查,测定其颈总动脉、颈内动脉内—中膜厚度(IMT)及内径,颈动脉粥样硬化斑块的发生情况及斑块性质,采用全自动生化分析仪测定血TC、TG、HDL-C及LDL-C水平。结果 VaD组颈总动脉IMT及颈内动脉IMT均明显大于对照组,颈总动脉及颈内动脉内径均明显小于对照组(P均<0.05);VaD组斑块发生率明显高于对照组(P<0.05);TC、TG、LDL-C水平均明显高于对照组、HDL-C明显低于对照组(P均<0.05)。结论颈动脉粥样硬化形成与VaD的发生密切相关。

Objective To investigate the effects of carotid artery atherosclerosis on the occurrence and development of vascular dementia （VaD）. Methods Color Doppler ultrasound examination was conducted in 61 patients with vascular dementia （VaD group） and 70 controls （control group）. The value of common carotid artery （CCA）, internal carotid ar- tery （ICA） intimal-medial wall thickness （IMT）, internal diameter, incidence of carotid artery plaque and nature of the carotid artery plaque were detected. The levels of total cholesterol （TC）, triglycerides （TG）, high-density lipoprotein cho- lesterol （HDL-C） and low density lipoprotein cholesterol （LDL-C） were detected by automatic biochemistry analyzer. Re- suits The common carotid artery IMT and internal carotid artery IMT of the VaD group were significantly greater than those of the control group, common carotid artery and internal carotid artery diameters were significantly less than those of the control group （ all P 〈 0.05 ） ; the incidence of plaque of VaD group was obviously higher than that of control group （ P 〈 0.05） ; TC, TG, LDL-C of VaD group were significantly higher than those of the control group, but HDL-C was significant- ly lower than that of the control group （ all P 〈 0.05）. Conclusion Carotid artery atherosclerotic formation is closely relat- ed to the occurrence of VaD.