局部晚期宫颈癌新辅助化疗不同给药途径的疗效分析

Curative Effect of Neoadjuvant Chemotherapy with Venous and Arterial Way for Locally Advanced Cervical Cancer

目的探讨局部晚期宫颈癌新辅助化疗的最佳给药途径。方法对124例局部晚期宫颈癌患者,采用不同给药途径化疗(65例行静脉化疗,59例行动脉插管化疗),比较其近远期疗效。结果静脉化疗和动脉插管化疗的总有效率、症状缓解率、骨髓抑制发生率、神经毒性发生率、手术切除率、出血量、1年无瘤生存率、5年存活率比较均无统计学差异;静脉化疗的胃肠道反应发生率、2年无瘤生存率高于动脉插管化疗;从开始化疗到手术历经时间静脉化疗长于动脉插管化疗,但住院总费用少于动脉插管化疗。结论局部晚期宫颈癌静脉给药新辅助化疗的近远期疗效好,操作方便,经济实用,值得推广。

Objective To investigate the best route of administration of neoadjuvant chemotherapy for locally-advanced cervical cancer. Methods 124 locally-advanced cervical cancer patients were divided into 2 groups ： intravenous chemotherapy group was 65 cases, and arterial chemotherapy group was 59 cases. The short-term and long-term efficacy of the 2 groups were compared. Results The total effective rate, remission rate, myelosuppression, neurotoxicity, resection rate, blood loss, 1-year disease free survival rate and 5-year survival rate of the 2 groups had no statistical difference. Gastrointestinal reaction and 2-year disease free survival rates of the intravenous chemotherapy group were higher than those of the arterial chemotherapy group. The time from beginning of chemotherapy to operation of the intravenous chemotherapy group were longer than that of the arterial chemotherapy group, while cost of hospitalization of the intravenous chemotherapy group were less than that of the arterial chemotherapy group. Conclusion Neoadjuvant chemotherapy for locally-advanced cervical cancer is effective, practical and economical, it is worthy of promotion.