慢性阻塞性肺疾病合并肺癌的临床病理特征分析

Chronic Obstructive Pulmonary Disease and Lung Cancer Relationship Analysis

目的分析慢性阻塞性肺疾病(COPD)合并肺癌的临床病理特征。方法回顾性分析100例慢性阻塞性肺疾病合并肺癌患者的临床资料。结果 100例慢性阻塞性肺疾病合并肺癌患者中82例有吸烟史,18例无吸烟史;COPD分级:15例为I级、64例为Ⅱ级、17例为Ⅲ级、4例为IV级;病理学结果:鳞癌46例、腺癌38例、小细胞癌11例、5例为其他;TNM分期:IA+IB期24例、ⅡA+ⅡB期27例,ⅢA+ⅢB期36例、Ⅳ期13例。其中56例行手术治疗、31例给予放疗及全身化疗、4例行中医治疗、7例给予对症、支持治疗、2例自动放弃治疗。结论 COPD合并肺癌患者早期缺乏特异性,临床诊断较为困难,对患者进行全面系统检查,可提高早期确诊率,及时给予积极的合理治疗,以提高患者生活质量,延长患者生命。

Objective To investigate the clinicopathological characteristics of chronic obstructive pulmonary disease （COPD） and lung cancer. Methods Clinical data of 100 patients with chronic obstructive pulmonary disease and lung cancer were retrospectively analyzed. Results Among 100 patients, there were 82 cases with a history of smoking and 18 cases without smoking history;COPD elassification：15 cases were grade Ⅰ ,64 cases were grade Ⅱ , 17 cases were grade Ⅲ ,4 case were grade Ⅳ ;the pathology results：there were 46 cases of squamous cell carcinoma,38 cases of adenocarcinoma, 11 cases of small cell carcinoma, and 5 cases of other pathological types of cancer ; the TNM staging ： there were 24 cases of stage Ⅰ A ＋ Ⅰ B, 27 cases of stage Ⅱ A ＋ Ⅱ B,36 cases of stage Ⅲ A ＋Ⅲ B, and 13 cases of stage Ⅳ. 56 patients were taken to surgery,31 patients received radiotherapy and systemic chemotherapy,4 patients received Chinese medicine treatment,7 patients received symptomatic and supportive treatment, and 2 patients gave up treatment. Conclusion COPD and lung cancer lacks early specific clinical manifestation, and the clinical diagnosis is difficult. Patients should receive comprehensive examination to improve the early diagnosis. Reasonable and positive treatment can improve the patients＇ quality of life and prolong patients＇lives.