胃癌Oct-4、β-catenin表达及其与术后复发转移的关系

Expression of Oct-4 and β-catenin in gastric cancer and the relationship with relapse and metastasis

目的探讨胃癌组织中Oct-4、β-catenin表达情况及其对术后复发转移的预测作用。方法采用免疫组化方法检测100例经手术切除的胃癌组织中Oct-4和β-catenin蛋白表达情况,并分析其与临床病理特征和无病生存时间(disease free survival,DFS)的关系。结果 Oct-4表达与患者的性别、年龄,肿瘤的发生部位、分化程度及淋巴结浸润无关,与T分期(P=0.023)及复发转移相关(P=0.035),差异有统计学意义。β-catenin表达水平与患者性别、年龄、肿瘤部位及分化程度无关,与T分期、淋巴结浸润及复发转移相关,差异有统计学意义(P值分别为0.006、0.019、0.011)。生存分析显示Oct-4和β-catenin的表达与患者术后复发转移相关,且二者均阳性表达者其术后复发转移率高于任意单阳者,二者均阴性表达者其复发转移率最低。结论 Oct-4与β-catenin联合检测对胃癌患者术后复发转移具有一定的预测作用。

Objective To investigate the expression of Oct-4 and 13-catenin in gastric cancer and the relationship with relapse and metastasis after operation. Methods Immunohistochemical analysis was used to evaluate the expression of 13-catenin and Oct-4. The correlation of 13-catenin and Oct-4 expression with patients＇ gender, age, the location of tumor, differentiation, T stage, lymphatic infiltration and metastasis was analyzed. Results The Oct-4 protein expression was associated with T stage（P=0.023） and metastasis （P=0.035）, but not with gender, age, the location of tumor, differentiation or lymph node invasion（all P〉0.05）. β-catenin expression was not correlated with gender, age, the location of tumor or differentiation in the 100 gastric cancer, but was related to T stage, lymphatic infiltration and metastasis（P= 0.006, 0.019, 0.011）. The survival analysis showed that β-catenin and Oct-4 expression was closely associated with prognosis of patients, and metastatic rate in positive expression was higher than negative expression. Conclusions Oct-4 and β-catenin both are a hopeful metastatic predictor for patients with gastric cancer.