肝硬化患者凝血指标与肝硬化程度关系研究

Study on the relationship between coagulation indexes in patients with liver cirrhosis of liver cirrhosis

目的研究肝硬化患者中凝血功能的变化对肝硬化病变程度的评估作用。方法以68例肝炎患者及49例正常健康体检人员为对照,观察76例不同Child-pugh分级肝硬化患者凝血功能的改变,研究凝血指标与肝硬化Child-pugh评分相关性。结果肝硬化组、肝炎组及对照组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)比较差异有统计学意义(P<0.05);肝硬化组不同Child-pugh分级的PT比较差异有统计学意义(P<0.05),C级的APTT、TT、FIB均高于A级及B级;PT与Child-pugh评分呈正相关(r=0.526,P<0.05)。结论凝血指标一定程度反映肝硬化患者肝脏的储备能力及病变的严重程度,监测肝硬化患者的凝血功能对患者病情评估、治疗均有重要的临床意义。

Objective To study the coagulation function in patients with cirrhosis for the assessment of the severity of cirrhosis of the liver function. Methods 68 cases of hepatitis patients and 49 cases of normal healthy volunteers as controls, observed 76 ea- ses of different Child-pugh classification changes in coagulation function in patients with cirrhosis, and liver cirrhosis coagulation studies Child-pugh score correlation. Results Cirrhosis, hepatitis group and the control group PT, APTT, TT, FIB were statisti- cally significant （P〈0.05）; cirrhosis Child-pugh classification of different groups of A, B, C three groups were statistically PT difference （P〈0.05）, APTT, TT, FIB C level was higher than class A and class B; PT with Child-pugh score was positively cor- related （r=0. 526,P〈0.05）. Conclusion Coagulation to a certain extent reflect the reserve capacity in patients with cirrhosis of the liver and the severity of disease, monitoring of coagulation in patients with cirrhosis on the patient＇s condition assessment, treatment has important clinical significance.