东莞地区女性宫颈人乳头瘤病毒感染及基因型别分布情况分析

Analysis of the infection and genotype distribution of HPV in Dongguan women

目的了解东莞地区女性人乳头瘤病毒(HPV)各基因型别的感染和分布情况,为东莞地区HPV分子流行病学研究提供依据。方法采用导流杂交基因芯片技术对4 675例女性宫颈脱落细胞标本进行检测,并对结果进行分析。结果 4 675例临床标本共检出阳性1 180例(25.24%,1 180/4 675),单一型别感染892例(19.08%,892/4 675),288例(6.16%,288/4 675),其中高危型HPV 601例(12.86%,601/4 675,不含多重感染);21种型别均被检出,其中HPV52、16、58、33、18是感染率较高的高危型;感染率较高的低危型别有HPV53、CP8304、6、11。不同年龄组之间感染率有显著差异。结论普及早期筛查,对感染患者进行跟踪随访,控制HPV的感染是预防或降低宫颈病变的有效途径。

Objective To study the infection and genotypes distribution of HPV in Dongguan women so as to provide the basis for HPV molecular epidemiological studies in Dongguan city. Methods 4 675 cytology specimens of uterine cervix were collected for 21 HPV DNA types detection by DNA flow-through hybridization genotyping technique,and the results were analyzed. Results Among 4 675 specimens, the infection rate of HPV was 25. 24% （1 180/4 675）. The single type infection rate of HPV was 19.08%（892/4 675）. The multiplicity infection rate of HPV was 6. 16% （288/4 675）. The infection rate of high-risk type was 12.86%（601/4 675）,in addition to the multiplicity of infection. All of 21 HPV types were found. The top five common high risk types were HPV52, HPV16, HPV58, HPV33, and HPV18, respectively. The top four common low-risk types were HPV53, HPV CP8304, HPV6, and HPV11, respectively. The infection rates were significantly different between the different age groups. Conclu- sion Popularizing early screening,following up the infected patients and control the infection of HPV were effective way of preven- ting and reducing cervical lesions.