海藻酸钠/淀粉复合微球的制备及性能研究

Research on synthesis and performance of SA/ST microspheres

以SA和ST为基质材料制备SA／ST复合微球，由单因素固定变量实验对SA／ST复合微球的合成进行研究，得到最佳实验条件为：总质量分数为6％，SA、ST质量比例为3：1。由红外光谱分析样品的化学结构，发现SA和ST之间通过氢键作用复合。研究结果表明，SA和ST总质量分数为6％时，微球有较高的包埋率和载药量，分别为65．00％和3．23％。载药微球在5～6h就可以达到完全释药，实验表明随着总质量分数增大微球的释药率降低。复合微球的溶血率为1．9％，小于国家标准5％，证明SA／ST复合微球有较好的血液相容性。

The SA/ST composite microspheres were synthesized with sodium alginate and starch. The syntheses of SA/ST microspheres were studied by experiment of fixing single factor. The results showed that excellent conditions of SA/ST microspheres were the total mass of 6%, the mass fraction of SA to ST of 3 ： 1. SA and ST made interaction through hydrogen bond by FTIR. The result showed that when SA/ST total mass fraction of 6 %, microspheres had better encapsulation efficiency and drug loading rate,i, e. 65.00% and 3. 23% respectively. The drug-loaded microspheres could release completely in 5-6 hours. The result demonstrated that the drug releasing efficiency of microspheres decreased with the increasing of the total mass fraction. The hemolysis ratio was 1.9%,less than the national standard of 5 %. It indicated that SA/ST mierospheres were hemocompatible.