疱疹病毒蛋白激酶功能的研究进展

Study progress on the herpesvirus protein kinases

丝氨酸/苏氨酸激酶存在于所有已知的疱疹病毒中,它们具有多种功能,参与病毒感染的整个过程,尤其是病毒与机体的相互作用。主要闸述了两类保守的疱疹病毒丝氨酸/苏氨酸激酶(单纯疱疹病毒HSV的UL13激酶和US3激酶)在病毒感染过程的重要作用。两者都参与调控细胞和病毒基因的表达,介导病毒衣壳出核以及免疫逃避。虽然这些激酶对病毒在体外培养细胞中复制的影响各不相同,但是对于病毒的毒力非常重要,因此,可用作抗病毒药物设计的靶位。

All known herpesviruses encode serine/threonine protein kinases. These kinases are multifunctional, which act on the viral infection, especially on the interaction between viruses and their hosts. In this article, two types of conserved serine/threonine protein kinases （UL13 and US3 of herpes simplex virus） of herpesviruses were described. Both of them participate in regulating the expression of cellular and viral genes, and mediating nuclear egress of viral nucleocapsids and evasion of the host immune response. Although the influence of these kinases on viral replication in cell cultures is variable, they invariably play important roles in virus virulence. So, they are potential as antiviral drug targets for treating herpesvirus-associated diseases.