炎性因子与阿尔茨海默病

Inflammatory cytokines and Alzheimer's disease

阿尔茨海默病(Alzheimer's disease,AD)是一种老年人易患的中枢神经系统退行性疾病,其主要临床表现为不可逆性、进行性的记忆力衰退,目前发病机制不清。AD患者脑内存在异常高水平的炎性因子及其受体、补体、调节蛋白以及化学因子等免疫炎性的标志物,提示炎性因子可能与AD的发病过程密切相关。综述了近年来有关炎性因子与AD发生发展关系的研究进展。

Alzheimer＇s disease （AD） is a neurodegenerative disorder of the central nervous system and predominantly occurs in the elderly, but so far the pathogenesis is still unknown mostly. Previous studies indicate that abnormally high levels of inflammatory cytokines and their receptors, complements and regulatory proteins as well as immune inflammatory markers have been observed in AD brains, suggesting a potential correlation between inflammatory cytokines and AD. Herein in this paper we reviewed the correlation between inflammatory cytokines and the occurrence and development of AD.