SOCS-3在哮喘Th1/Th2免疫失衡中的作用研究进展

Research progress of SOCS-3 on the imbalance of Th1/Th2 in asthma

支气管哮喘(简称哮喘)是一种以Th1/Th2免疫失衡、Th2优势应答为特征的慢性气道炎症性疾病。细胞因子信号转导抑制因子3(SOCS-3)是一类与细胞因子JAK/STAT信号转导途径有关的负反馈调节因子,参与细胞固有免疫、获得性免疫和炎症反应。近年来研究发现,在哮喘的发生发展中SOCS-3均表现出分子水平或功能的异常,揭示SOCS-3可作为哮喘诊断和治疗的新靶点。就SOCS-3与哮喘的关系研究进展进行综述,讨论其在哮喘Th1/Th2免疫失衡中的作用。

Bronchial asthma （asthma） is a kind of chronic airway inflammatory diseases, characterized by immune imbalance of Thl/Th2 cytokine and Th2-skewed immune response. SOCS-3 is a negative feedback regulatory protein related to the cytokine signaling transduction pathways of JAK/STAT, which is mainly involved in innate and adaptive immunity and inflammation. In recent years, researches have found that SOCS-3 has an abnormal molecular level or impaired function during the onset and development of asthma. Therefore, SOCS- 3 may serve as a therapeutic and diagnostic target for asthma. In this review, the advances of research on relationship between SOCS-3 and asthma were summarized, and the roles of SOCS-3 in the imbalance of Thl and Th2 in asthma were discussed.