前列腺凋亡反应蛋白-4抗肿瘤作用研究进展

Study progress in the antitumor effects of Par-4

前列腺凋亡反应基因-4(prostate apoptosis response gene-4,par-4)是从凋亡的前列腺癌细胞中分离出来的一种基因,该基因编码的产物是前列腺凋亡反应蛋白4(Par-4)。Par-4可通过细胞内、外途径调节各种分子表达,诱导癌细胞凋亡,选择性抑制肿瘤细胞生长,因此,Par-4的表达与肿瘤的发生、发展及预后有密切的联系。Par-4在治疗恶性肿瘤中表现出良好的肿瘤细胞靶向杀伤效应,对正常组织细胞无明显影响,故具有极其重要的应用价值。就Par-4特异性诱导肿瘤细胞凋亡及其潜在抗肿瘤作用的进展进行综述。

Prostate apoptosis response gene-4 （par-4） was first identified from apoptotic prostate cancer cells. Prostate apoptosis response protein-4 （Par-4） can induce tumor cell apoptosis and selectively inhibit tumor cell growth through intracellular and extracellular pathways. Thus, Par-4 is involved in the occurrence, development and prognosis of tumors. Furthermore, Par-4 exhibits excellent malignant tumor cell killing effects without influencing normal cells and tissues. This paper reviews the progress of Par-4 specially inducing tumor cell apoptosis and its potential roles in anti-tumors.