长方案垂体降调节时间对体外受精-胚胎移植结局的影响

Effect of pituitary down-regulation of long protocol controlled ovarian stimulation on the outcomes of in-vitro fertilization and embryo transfer

目的：探讨长方案垂体降调节时间的长短是否会对体外受精-胚胎移植的结局产生影响。方法：回顾性分析192个应用黄体中期长方案进行控制性超促排卵的IVF—ET周期，根据Gn启动前垂体降调节时间长短分为3组：A组，14～15d（53例）；B组，16～18d（98例）；C组，〉18d（41例），比较组间的促排卵情况及妊娠结局。结果：3组间注射HcG日子宫内膜厚度，获卵数，受精率，优胚率。移植胚胎数，妊娠率，种植率等均无统计学差异（P〉0．05），Gn总量，Gn用药时间C组高于A，B两组，差异有统计学意义（P〈0．05）。结论：长方案垂体降调节时间长短不影响IVF—ET的妊娠结局，但垂体过度抑制者需增加Gn用量及时间。

Objective To explore the effect of different duration of pituitary down-regulation of long protocol controlled ovarian stimulation on the outcomes of in-vitro fertilization and embryo transfer. Methods A retrospective analysis was conducted on a total of 192 IVF-ET cycles. The cycles were divided into three groups according to the days of successful pituitary down-regulation was confirmed. The three groups were group A （ 14 to 15 days, 53 cycles）, group B （16 to 18 days, 98 cycles）, and group C （〉18 days, 41 cycles）. Results There were no significant differences in endometrial thickness on the day of hCG administration, number of oocytes retrieved, fertilization rate, high-quality embryo rate, number of embryo transfer, pregnancy rate, and implantation rate among the three groups （P 〉 0.05）. The tatal dosage of Gn were greater and the time of Gn uses were longer in group C than in groups A and B （P 〈 0.05）. Conclusions Different duration of pituitary down-regulation can not affect the outcomes of in-vitro fertilization and embryo transfer. However, dosage and duration of Gn therapy should be increased in the patients with over suppression.