摘要
目的 观察苦参素注射液治疗慢性乙型肝炎 (CHB) 6个月的临床疗效。 方法 48例CHB患者 ,用苦参素注射液 6 0 0mg ,肌肉注射 ,1次 /天 ,共 6月 ;另选择 36例CHB患者 ,采用一般保肝降酶药治疗 6个月作为对照。 结果 两组在改善症状、体征和恢复肝功能方面效果明显 (P >0 .0 5 )。苦参素组HBeAg与HBVDNA在治疗 3个月和 6个月后 ,阴转率分别是 41.7%、39.6 %和 6 0 .4%、5 8.3% ,比对照组 16 .7%、13.9%和 2 2 .2 %、16 .7%明显增高 (P <0 .0 1)。治疗组 6个月时HBeAg与HBVDNA阴转率均较 3个月时高 (P <0 .0 5 )。治疗组HBeAg/抗 -HBe血清转换率达 5 8.6 %。除注射部位的疼痛、硬结外 ,未见其他不良反应。 结论 苦参素注射液治疗CHB有确切疗效 ,如剂量大 (6 0 0mg)、疗程长 (6个月 ) ,其治疗效果更令人满意。
Objective To observe the clinic therapeutic effects of oxymatrine(OM)on chronic hepatitis B(CHB)in 6 months. Methods To compare 48 cases with CHB treated by OM injection 600 mg,i.m,once per day for 6 months with 36 cases with CHB treated by usual BAOGANJIANGMEI methods. Results There is no distinct difference(P>0.05)between the two groups in improving symptoms and signs and recovering liver function.After 3 and 6 months,thd negative rate of HBeAg and HBV DNA in treated group is 41.7%,39.6% and 60.4%,58.3%,it's obviously higher than the controlled group,which is 16.7%,13.9%and 22.2%,16.7%.There is a distinct difference(P<0.01)between the two groups.The negative rate of HBeAg and HBV NDA at 6th month is higher than is was at 3rd month in treated group(P<0.05).The serum conversion rate of HBeAg/anti-HBe in the treated group is 58.6%.The main problem of 6 months' period of treatment is ache and aclerosis of the injection spot,except that,there is no other side reaction. Conclusion There is a obvious therapeutic effect treating CHB with OM under high doses(600 mg)and long period of treatment(6 months).
