影响骨折患者围手术期血栓前状态分子标志物检测指标的多因素回归分析

Multivariate Regression Analysis of Prethrombotic State(PTS) Molecular Markers for Patients with Fracture During the Perioperative Period

目的探寻影响骨折患者围手术期血栓前状态(PTS)的有关因素。方法对196例骨折患者进行临床观察,于手术前1 d及术后3 d分别采集标本进行血栓前状态分子标志物检测,进而将调查表所得数据进行统计学分析。结果 196例患者中63例发生血栓前期状态,发病率为32.14%。未发生有症状的深静脉血栓形成(DVT)和肺栓塞(PE)。单因素分析显示,18个变量中14个变量与PTS有关,性别、就诊时间、神经损伤、镇痛治疗与PTS无关。多因素分析,筛选出7个骨折患者围手术期PTS的危险因素:高龄、体质量指数>27、吸烟、高血脂症、下肢骨折、血管损伤、输血。结论高龄、肥胖、吸烟、高脂血症、下肢骨折、血管损伤、输血等因素为PTS高危因素,在临床工作中应有针对性地进行预防。

Objective： To explore the factors related with the Prethrombotic State （PTS） Molecular Markers for patients with fracture. Methods： 196 patients with fractures who met inclusion criteria and treated operatively in our institute were statistically analyzed. The Prethrombotic State （PTS） Molecular Markers were determined 1 day before surgery and 3 day after surgery. Results： The incidence rate of PTS in patients with fractures was 32.14% （63/196） ,and there was no symptomatic Deep Venous Thrombosis （DVT） and Pulmonary Embolism （PE）. 14 variables were related with PTS in univatiate analysis. The gender,time from injury to visiting , nerve injury, anal- gesic treatment had no relation with PTS. The eld,Body Mass Index 〉27,smoking,hyperlipoidemia,fracture of lower limb,injury of blood vessel,blood transfusion had relation with PTS in multivariate analysis. Comclusion： The eld,Body Mass Index 〉27,smoking,hyperlipoidemia,fracture of lower limb,injury of blood vessel,blood transfusion are the high risk factors related with PTS. We should perform the targeted prevention in the clinic work.