葛根素在糖尿病肾病患者中的药动学

Study on the pharmacokinetics of puerarin in patients with diabetic nephropathy

目的 :观察葛根素在糖尿病肾病患者体内的药物动力学特性。方法 :7名患者均给予葛根素 5mg·kg-1(体重 ) ,溶于10 0ml生理盐水中 ,单次静脉滴注 ,6 0min滴完。用高效液相色谱法测定滴注过程中及停滴后不同时间的血清药物浓度 ,用3p87程序拟合计算。结果 :葛根素在糖尿病肾病患者体内表现为二室模型。其主要药动学参数为 :t1/ 2α=(2 .7± 1.0 )min ,t1/ 2 β=(141.1± 34.7)min ,Vc=(0 .0 0 3 7± 0 .0 0 2 9)L·kg-1,CL =(0 .0 0 0 6± 0 .0 0 0 2 )L·kg-1·min-1。结论

OBJECTIVE:The pharmacokinetics of puerarin was studied in the patients with diabetic nephropathy. METHODS:The concentration of puerarin in serum was determined by reversed phase high performance liquid chromatography.After an ivgtt does(5 mg·kg -1 ,60 min) was given to each 7 patients with diabetic nephropathy, the concentration data obtained were fitted with 3p87 programon computer.RESULTS:The disposition of puerarin was conformed to a two compartment model with t 1/2α =( 2.711 ± 1.020 ) min, t 1/2β =( 141.1 ± 34.7 )min, V C=( 0.003 7 ± 0.002 9 ) L·kg -1 , CL =( 0.000 6 ± 0.000 2 ) L·kg -1 ·min -1 .CONCLUSIONS:The pharmacokinetics of puerarin in the patients with diabetic nephropathy changess significient.[