胃癌预后相关影响因素新进展

New Progress of the Prognosis of Gastric Cancer Related Influence Factors

胃癌患者由于早期缺乏特征性症状，因此我国临床诊断的胃癌病例大多数已为中晚期。自1880年Billroth首例胃切除手术成功以来，经过将近一个世纪的不断发展，以外科手术切除为主的综合治疗方式已成为治疗胃癌的重要手段，但是总体来说胃癌患者的预后仍是处于不容乐观的状态。有报道显示胃癌患者术后5年生存率通常仅为10%~20%，因此胃癌治疗的疗效及其预后仍是临床关注的热点问题。胃癌患者预后跟多种影响因素有关，包括患者性别、年龄、肿瘤大小及部位等一般因素和肿瘤组织类型、浸润程度、TNM分期、淋巴结转移等病理因素。本文通过对上述两类影响因素的最新研究进展作一综述，总结影响胃癌患者预后的重要因素。

Most of the gastric cancer（GC）patients in clinical are in middle and advanced stage due to the lack of characteristic symptoms in early stage. Since the first gastrectomy was successfully operated by Billroth in 1880,the surgical operation based comprehensive treatment was became the essential measures for GC treatment after development for nearly one century,however,the prognosis was still not optimistic. Reports said that the postoperative survival rate of GC patients in 5 years was only 10%-20%. Therefore,the efficacy and prognosis of GC treatment remains the clinical concerned hot topic. The prognosis of the GC patients was related to many factors,which including the general factors such as gender,age,tumor size and location,and the pathological factors such as type of tumor tissue,infiltration degree,TNM staging and lymphatic metastasis. This study aims to make a review for the latest research development of two types of influence factors mentioned above,and summarize the important factors which can affect the prognosis of GC patients.