聚乳酸改性壳聚糖及其在生物医学领域的应用

Advance of Poly (lactic acid) Modified Chitosan in the Field of Biomedical

壳聚糖(CS)和聚乳酸(PLA)具有许多独特的性能,包括可生物降解性、良好的生物相容性,对人体无刺激、无毒,是一种绿色生物医药材料,具备潜在的应用价值。将二者单独用于医药领域优势不是很显著,而聚乳酸改性壳聚糖的产物及其衍生物能够很好地融合二者的优点,改性后能得到综合性能更好的生物医学复合材料。本文从聚乳酸改性壳聚糖的角度,综述了壳聚糖和聚乳酸的性质、改性原因、改性现状、改性产物的性能以及在医药领域的一些应用,重点介绍了改性产物在药物缓释方面的应用,并指出今后改性材料方面应注意的问题和发展趋势。

.Chitosan（CS） and poly（lactic acid）（PLA） were green biomedical materials with potential value for their unique properties including biodegradability, excellent biocompatibility, nonirritant, non-toxic. The advantage of applying separately them to the field of medicine was not significant, but the product of PLA modified CS and its derivatives had can be well consolidated the advantages of both, the better overall performance of the biomedical composite material can be obtained after modification. The property of CS and PLA, the modified reason and situation, application and properties of modified Chitosan in pharmaceutical field were summarized from the perspective of PLA modified CS, focuses on modification of product applications irt drug delivery and pointed out the problems and develop tendency of modified materials.