摘要
颅颌面软硬组织缺损是临床常见病和多发病,对患者容貌和功能均有严重妨碍。其修复重建是涉及多学科的综合性临床难题,目前仍有不少问题亟待解决。组织工程的发展为颅颌面修复重建带来了新的思路,而种子细胞来源是组织工程研究的首要问题。近年来,脂肪间充质干细胞因其具有来源广泛、取材方便、诱导条件下多向分化、扩增能力强等优点而成为较为理想的种子细胞。本文就脂肪间充质干细胞在颅颌面修复重建中的应用进展作一综述。
Craniomaxillofacial hard and soft tissue defects are clinically common and frequently encountered diseases that seriously affect the appearance and function of patients. Restoration and reconstruction of craniomaxillofacial hard and soft tissues are comprehensive clinical problems that require a multi-disciplinary approach and are faced with many unresolved issues. Development of tissue engineering has introduced new concepts to craniomaxillofacial restoration and reconstIuction. Tissue engineering primarily aims to determine suitable seed cells. Recently, adipose-derived mesenchymal stem cells （AdSCs） were found to be relatively ideal seed cells because they are easy to obtain from numerous sources and have multiple potencies under certain inducing circumstances and high augmenting ability. This review provides an overview of the application of AdSCs in craniomaxillofacial restoration and reconstruction.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2013年第6期644-647,共4页
West China Journal of Stomatology
基金
国家自然科学基金资助项目(81070802
81271096)
中央高校基本科研业务费专项资金资助项目(2011)
关键词
脂肪间充质干细胞
颅颌面
组织工程
分化
adipose-derived mesenchymal stem cells
craniomaxillofacial
tissue engineering
differentiation
