摘要
细胞毒素相关基因A蛋白(cytotoxin-associated gene A,CagA)是幽门螺杆菌重要毒力因子之一,亦被称为细菌癌蛋白,可通过Ⅳ型分泌系统易位进入胃上皮细胞,干扰多条信号转导通路.细胞外信号调节激酶(extracellular signalregulated kinase,ERK)通路在细胞信号传导中处于枢纽地位,癌蛋白CagA可通过激活ERK信号通路对细胞的增殖、凋亡、分散和转移等生物学行为产生影响,与胃癌的发生、发展有关.本文对CagA、ERK信号通路与胃癌的研究进展做一综述.
Cytotoxin-associated gene A （CagA） of Helico- bacter pylori is the first identified bacterial oncop- rotein that plays a critical role in gastric carcino- genesis. Upon delivery into gastric epithelial cells via type IV secretion, CagA can interfere with a number of host signaling pathways. Extracellular signal-regulated kinase （ERK） signaling pathway is a hub in cellular signal transduction, through which CagA elicits a series of cellular events in- cluding cell proliferation, apoptosis, scatter and metastasis, all of which are associated with gastric carcinogenesis. Here we perform a review of the association between CagA/ERK signaling path- way and gastric cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第31期3363-3368,共6页
World Chinese Journal of Digestology
基金
广东省自然基金资助项目
No.10452402301005604~~
