茵陈胆道汤治疗急性胆管炎的实验研究

Experimental Studies in Treating Acute Cholangitis with Yin Chen Dan Dao Tang

目的 :研究茵陈胆道汤治疗急性胆管炎的作用机理。 方法 :通过胆道插管注入大肠杆菌 ,将兔制成急性胆管炎模型 ,观察服用茵陈胆道汤后兔血浆纤维结合蛋白 (PFn)、胆总管肥大细胞计数的变化和胆管炎时胆汁血栓素和前列环素的改变。 结果 :服药组兔PFn和胆管肥大细胞计数明显高于对照组 (均P <0 .0 1) ;胆管炎时兔胆汁血栓素和前列环素均明显高于对照组 (均P <0 .0 1)。 结论 :茵陈胆道汤升高PFn 。

To study the therapeutic mechanism of Yin Chen Dan Dao Tang in treating acute cholangitis.Methods:The rabbit m odel of acute cholangitis was induced by challenged injecting Escherichi Coli in to the common duct.After oral administration of Yin Chen Dan Dao Tang the c hanges of plasma fibronectin(PFn),enumeration of mast cell in common bile duct and bile thromboxane A 2 and prostacyclin of the rabbits were observed.Results:After oral administration of Yin Chen Dan Dao Tang t he PFn and mast cell number in the common bile duct of rabbits were markedly inc reased as compared with the control group( P <0.01).The bile thromboxane A 2 and prostacyclin were markedly increased( P <0.01).Conclus ion:The therapeutic mechanism of Yin Chen Dan Dao Tang in treating acute cholangitis may be to increasc the PFn and mast cell number in the common bile duct and to decrease the bile thromboxane A 2 and prostacycline.