摘要
目的 :通过动物实验方法观察丹参对肢体缺血再灌注所致肺损伤的保护作用。 方法 :110只Wistar大鼠随机分成正常对照 ,缺血 3h和缺血 3h用丹参 3个组。实验组于缺血、再灌注 1、2、3和 2 4h取材 ,光镜下对比观察和组织学评估。结果 :肢体缺血和再灌注后 ,实验组肺泡隔增厚、水肿 ,毛细血管扩张、充血、大量多核白细胞浸润 ,贴壁 ,部分肺不张。用丹参组的病理改变明显轻于未用丹参组。 结论
AnexperimentalstudytoobservetheprotectiveeffectofRadixSalviaMiltiorrhiza(RSM)onlunginjury afterlowerlimbischemicreperfusion .Methods :Wistarrats 110innumberweredividedintoacontrolgroup ,ischemia 3 -hourgroupandischemia 3hourgrouptreatedwithRSM .Thehistologicalassessmentoflungwasundertakenat0 ,1,2 , 3and 2 4hoursafterreperfusion .Results :Pulmonaryedema ,microvascularcongestion ,excessiveinfiltrationofpolymor phonuclearneutrophilandpartialpulmonarycollapsewerefoundinexperimentalgroupsat 0 ,1,2 ,3and 2 4hoursafter reperfusion .TherewasasignificantlesseningofthepulmonaryinjuryinthegrouptreatedwithRSM .Conclusion :Itis suggestedthatRSMcanalleviatethelunginjuryafterlowerlimbischemicreperfusioin .
出处
《中国中西医结合外科杂志》
CAS
2000年第6期412-414,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
兰州军区资助课题
