阿尔茨海默病患者脑脊液中Tau蛋白的含量及意义

Detection of Tau Proteins in Alzheimer's Diseasc Cerebrospinal Fluid with a Sensitive ELISA

目的：Ａｌｚｈｅｉｍｅｒ病（ＡＤ）实验室诊断指标测定。方法：ＥＬＩＳＡ测定４０例ＡＤ患者，２６例梗塞性痴呆（ＭＩＤ）患者，５８例正常人脑脊液Ｔａｕ含量。结果ＡＤ患者、ＭＩＤ患者脑脊液Ｔａｕ 蛋白含量均明显高于正常对照组（Ｐ＜０．００１），而ＡＤ组与ＭＩＤ组差别无统计意义（Ｐ＞０．０５）。ＡＤ组Ｔａｕ蛋白含量与病程呈正相关关系（Ｐ＜０．０１，ｒ＝０．４４），ＭＩＤ组未发现此相关关系（Ｐ＞０．ｌ）．三组测定值与年龄均无相关关系。结论：Ｔａｕ蛋白含量在 ＡＤ患者脑脊液中明显升高，在 ＭＩＤ组亦增高，故单纯测定Ｔａｕ蛋白难以鉴别ＡＤ和ＭＩＤ。作者单位：卫生部课题资助基金（批准编号：９４－１－２４６，卫生部九五攻关课题）

Aim: To determine a specific experimental measurement of Alzheimer's disease (AD). Methods: The levels of Tau protein in CSF was determined in 40 AD patients, 26 MID patients and 58 normal controls with ABC-ELISA. Results :The CSF-Tau levels were significantly elevated in AD and MID patients. There was no significant difference between the two groups (P>0. 05 ). There was correlation between the levels of Tau protein and course in AD. Conclusion: Levels of CSF-Tau in AD patients were significantly higher than normal controls, so were those of MID patients. So simple CSF-Tau detection is not a specific experimental diagnosis of AD.