盐酸椒苯酮胺致畸敏感期毒性试验

Teratology study of piperphentonamine hydrochloride

目的评价盐酸椒苯酮胺的安全性,了解其有否致畸变作用。方法用成年Wistar大鼠,从受孕第7天起隔日1次尾静脉注射盐酸椒苯酮胺1、5、20 mg/kg,共4次,覆盖胚胎的器官形成期。于受孕第20天处死动物,解剖观察母鼠及胎鼠内脏与骨骼。结果未见畸变和胚胎毒性。结论盐酸椒苯酮胺的致畸试验为阴性。

Objective To examine reproductive toxicity and teratology of piperphentonamine hydrochloride. Methods 1, 5, 20 mg/kg piperphentonamine hydrochloride were injected by caudal vein of adult Wistar rats from 7th after becoming pregnant for 4 times, covering embryonic period of organogenesis. The internal organs and skeleton of adults and foetus were dissected and observed after 20 days. Results Teratology or reproduction were all negative. Conclusions Piperphentonamine hydroehloride has no adverse effect on teratology or reoroduction.