摘要
核酸适配子是一类经SELEX技术筛选出来的寡聚核苷酸,其功能与单克隆抗体类似但在诸多方面明显优于抗体,可用于测定靶物质含量等。免疫球蛋白E(immunoglobulin E,IgE)是介导过敏反应的关键因子,IgE定量检测是临床诊断过敏性疾病的重要指标。该文主要综述了核酸适配子在IgE检测中的应用。
Aptamers are a new class of oligonucleotides screened by SELEX. The function of aptamers is similar to monoclonal antibody but superior in many aspects, therefore they can be used to determine the levels and influence the bioactivity of target material. Immunoglobulin E （/gE） is a key factor in allergic reaction, thus IgE level is an important indicator in diagnosis of allergic diseases. In this review, we mainly discussed the application of aptamers in detecting the IgE levels.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2013年第12期1088-1092,共5页
Immunological Journal
基金
国家自然科学基金(81202338)
河北省自然科学基金(H2013201128,C2010000248)
