呼吸道合胞病毒M蛋白核转运

Nuclear transport of the respiratory syncytial virus matrix protein

呼吸道合胞病毒(respiratory syncytial virus,RSV)是有包膜单股负链RNA病毒,是世界范围内婴幼儿主要呼吸道病原体,也是重度免疫抑制者或老年人发病致死的主要原因。RSV M蛋白是RSV非糖基化内膜结构蛋白,其核转运及调节在感染细胞的病毒组装方面起重要作用。M蛋白由IMP识别NLS序列介导核转入,通过与细胞核成分结合而存留在细胞核中,由Crm-1识别NES序列介导核转出,可能通过磷酸化调节其核转运。关于M蛋白核转运的研究,国内尚无相关文献,国外已基本研究出M蛋白核转运所需的介导因素。M蛋白核转运的研究对于利用此机理开发抗RSV复制的药物有利,此过程的机理仍需进一步研究。本文对M蛋白的核转运及其调节进行综述。

Respiratory syncytial virus （RSV） is a negative-sense single-strand RNA virus, which is a major pathogen cousing respiratory tract disease in the pediatric populations and also in profoundly immunosuppressed and elderly individuals. Matrix protein is a structural internal membrane protein, whose nuclear transportion and regulation play important roles in assembly of virus in RSV infected cells. Nuclear import of the matrix protein is mediated by NLS recognition of importin （IMP）, while nuclear export is mediated by Crml, which recognizes NES. Nuclear transport of the matrix protein maybe regulate by phosphorylation. Controling of the nuclear transport of M protein maybe an effective strategy for developping of new drugs. This article provides an overview of the progess of the nuclear transport of the matrix protein of RSV.