OCT比较高眼压和原发性开角型青光眼的视网膜神经纤维层厚度

Retinal nerve fiber layer thickness evaluation in ocular hypertensive eyes and primary open-angle glaucoma patients using optical coherence tomography

目的采用光学相干断层扫描技术(OCT)测得正常人、高眼压者和原发性开角型青光眼患者的视网膜神经纤维层(RNFL)的厚度并进行比较。方法选取门诊就诊的患者和正常志愿者,根据眼压、视野和视乳头形态分为正常组76名(152眼),高眼压组70例(109眼),原发性开角型青光眼组67例(112眼),采用OCT CIRRUS Zeiss分别测得3组的平均RNFL和4个象限的RNFL。结果正常组平均RNFL为(107.61±8.03)μm,高眼压组平均RNFL为(105.26±9.22)μm,原发性开角型青光眼组平均RFNL为(91.00±10.55)μm。正常人平均、上方和下方RNFL与原发性开角型青光眼患者比较差异有统计学意义(P<0.01);高眼压组与原发性开角型青光眼组之间平均RNFL比较差异有统计学意义(P<0.01);正常组和高眼压组之间平均RNFL比较差异无统计学意义(P>0.05)。结论通过对RNFL厚度的分析,为高眼压和原发性开角型青光眼的鉴别诊断提供帮助。

Objective To measure and compare retinal nerve fiber layer （RNFL） thickness by optical coherence tomography （OCT） in normal eyes, ocular hypertensive eyes, and primary open-angle glaucoma patients. Methods The RNFL thickness was measured in 3 groups： normal group （76 cases, 152 eyes）, ocular hypertensive group （70 cases, 109 eyes）, and primary open-angle glaucoma group （67 cases, 112 eyes）. RNFL measurements were taken with OCT CIRRUS Zeiss. Results The average values of RNFL thickness were （ 107.61± 8.03）μm, （ 105.26 ± 9.22）μm, and （91. 00±10.55）μm in normal eyes, ocular hypertensive eyes, and glaucomatous eyes, respectively. Compared normal eyes, RNFL average thickness, superior thickness, and inferior thickness showed significant differences in glaucomatous eyes （P 〈 0.01）. The RNFL average thickness was significantly different between ocular hypertensive eyes and glaucomatous eyes （P〈0. 01）, whereas there was no significant difference between normal and ocular hypertensive eyes （P 〉 0.05）. Conclusion The RNFL thickness measurement is a kind of very useful and objective method to differentiate ocular hypertensive and primary open-angle glaucoma.