结核分枝杆菌细胞壁糖复合物研究进展

Progress toward cell wall glycoconjugates of Mycobacterium tuberculosis

结核病是由感染结核分枝杆菌引起的、以呼吸道发病为主的慢性传染病,目前仍然是单一病原体感染发病致死率最高的感染性疾病,深入了解结核分枝杆菌的生理代谢及其致病机制是防控结核病传播的重要途径。结核分枝杆菌细胞壁上特殊的糖复合物在维持细胞壁结构和致病过程中发挥着极其重要的作用,因此已成为当今的研究热点。该文仅对结核分枝杆菌细胞壁上糖复合物作一综述,以期为结核分枝杆菌的相关基础研究及临床应用提供参考。

Tuberculosis （TB）, a chronic infectious disease mainly associated with respiratory tract, caused by Mycobacterium tuberculosis, is still the highest mortality infectious diseases of simplex cause today. Therefore a further understanding of physiological metabolism and pathogenesis of TB is critical to the control and prevention of TB spread. The special glycoconjugates in Mycobacterium tuberculosis＇s cell wall play an important role in the maintenance of cell wall integrity and its pathological process, thus becoming a focus of relevant researches. To provide a basis for basic research and clinical application of TB, the recent advance in major cell wall glyeoconjugates of Mycobacterium tuberculosis is summarized in this paper.