子宫内膜局部肾素-血管紧张素系统

Local Renin-angiotensin System in Endometrium

肾素-血管紧张素系统(renin-angiotensin system,RAS)是人体重要的体液调节系统,当这一系统出现紊乱易引发多种疾病。以往研究多偏重于全身RAS系统,近年来,局部RAS成为研究热点。子宫内膜相关研究表明,局部RAS参与子宫内膜周期性变化及生殖功能调节、维持妊娠期人体子宫稳态等一系列生理过程;并参与子宫内膜异位症、功能性子宫内膜出血、子宫内膜癌等病理生理过程。

Renin-angiotensin system （RAS） is an important humoral regulation system in human body, the disorder of this system could induce many diseases. Many previous studies focus on this circulating RAS system, local RAS becomes a research hotspot these years. Related studies have shown that local RAS participates in a series of physiological processes such as endometrial periodic changes, reproductive function regulation, and pregnant uterine body homeostasis. And local RAS also participates in the pathological process such as endometriosis （EMs）, functional endometrial bleeding and endometrial cancer.