米非司酮配伍米索前列醇与苯甲酸雌二醇在稽留流产清宫术前应用的临床效果比较

Comparison of Clinical Treatment Effect between Mifepristone Combining with Misoprostol and Estradiol Benzoate in Missed Abortion

目的:探讨米非司酮配伍米索前列醇在稽留流产清宫术前的临床应用效果。方法:回顾性分析52例米非司酮配伍米索前列醇加清宫治疗稽留流产(A组)的临床效果,并与32例苯甲酸雌二醇加清宫治疗稽留流产者(B组)进行疗效比较。结果:A组服药后6 h内胚胎排出27例(51.92%),宫颈软化扩张率为100%,手术时间为5.2±1.5 min,术中出血量为19.3±8.5 ml,术后出血时间为4.2±1.3 d,均1次清宫成功,疼痛程度轻,均未发生人工流产综合征(0%);B组服药后6 h内均未见胚胎排出(0%),宫颈软化扩张者占6.25%,清宫前需扩宫,手术时间为11.2±3.5 mim,术中出血量为60.0±10.6 ml,术后出血时间为10.1±2.3 d,26例(81.25%)1次清宫成功,疼痛程度明显及人工流产综合征发生率高(13.46%);各项观察指标与A组相比,均有显著统计学差异(P<0.01)。结论:米非司酮配伍米索前列醇在稽留流产清宫术前应用是一种简便、安全、有效的方法,值得推广。

Objective： To investigate the effect of mifepristone combining misoprostol in missed abortion. Methods： Totally 52 cases treated with mifepristone combining misoprostol （group A） and 32 cases treated with estradiol benzoate （group B） were retrospectively analyzed. Results： For group A, embryo aborted number in 6 h was 27 （51.92%）, cervical softening was 100%, time in surgery was 5.2 ± 1.5 min, amount of bleeding was 19.3 ± 8.5 ml, postoperative hemorrhage time was 4.2 ± 1.3 d, the curettage rate was 100%. For group B, embryo aborted number was 0 （0%）, cervical softening was 6.25%; expanding palace was needed before curettage. Time in surgery was 11.2 ± 3.5 min, amount of bleeding was 60.0 ±10.6 ml, postoperative hemorrhage time was 10.1 ± 2.3 d, the number of solography of cavity was 26 （81.25%）. The postoperative pain of group A was better and the incidence of abortion syndrome was lower, there was an obvious significance in the comprehensive function between the two groups （P〈0.01）. Conclusion： It is safe and effective to apply mifepristone combining with misoprostol in missed abortion which should be widely applied.