肠道大肠艾希氏菌超广谱β-内酰胺酶的检测与耐药性分析

ESBLs detection and analysis of drug resistance of Escherichia coli

目的 了解肠道大肠艾希氏菌及肺炎克雷伯氏菌ESBLs的携带情况.方法 细菌的鉴定和药敏试验采用仪器法.超广谱β－内酰胺酶(ESBLs)的检测采用纸片扩散法初筛,双纸片协同试验检测,Etest法确定.结果 207株菌中,ESBLs总检出率为13．5%(28株),其中,大肠艾氏菌ESBLs的检出率为11%,肺炎克雷伯氏菌为39%,后者明显高于前者.药敏结果显示：两种菌中产ESBLs比非产ESBLs耐药性要高.结论 肠道大肠艾氏菌和肺炎克雷伯氏菌ESBLs的携带比较严重,尤其是后者.

 Objective To investigate the ESBLs schleping situation of intestinal E coli and KI pneumonia． Methods The identification and MIC were detected by instrument ESBLs detection with slip diffusion were taken to primarily select double silp synergetic tests were identified by Etest method． Results In 207 strains total ESBLs positive rates were 13．5% 28 strains In which E coil ESBLs positive rates were 11% K1 pneumonia were 39% the Latter was distinct higher than the former． The results of drug sensitivity showed that the rates of drug resistance of ESBLs productive strains were higher than that of ESBLs nonproductive strains． Conclusion It was fairly sever to ESBLs schleping in intestinal E coil and K1 pneumonia and the latter was graver． 