糖尿病肾病患者血清视黄醇结合蛋白4水平变化及意义被引量：3

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摘要目的观察2型糖尿病肾病(DN)患者血清视黄醇结合蛋白4(RBP-4)水平变化,并探讨其临床意义。方法筛选2型糖尿病患者147例(观察组),其中单纯糖尿病35例、早期DN 34例、临床DN 31例、DN肾功能不全28例、DN血液透析19例,随机选择53例健康人作为对照组。检测两组血清RBP-4、血糖、血脂、血Scr、尿酸、BUN,并计算肾小球滤过率(eGFR)。结果血清RBP-4在观察组单纯糖尿病、早期DN、临床DN、DN肾功能不全、DN血液透析患者中分别为(50.26±6.29)、(66.39±12.81)、(76.16±19.20)、(104.64±10.57)、(114.52±33.08)μg/mL,均显著高于对照组的(17.01±1.67)μg/mL,P均<0.01;血清RBP-4水平与血清肌酸酐呈正相关(r=0.377,P<0.01),而与eGFR呈负相关(r=-0.436,P<0.01)。多元逐步回归分析发现,eGFR是血清RBP-4升高的独立相关因素。结论血清RBP-4有助于DN的早期诊断与病情判断。

作者雷琳郭静霞任巧华王欣

机构地区石家庄市第一医院

出处《山东医药》 CAS 2013年第44期68-70,共3页 Shandong Medical Journal

基金河北省石家庄市科学技术研究与发展支撑计划项目(101461433)

关键词 2型糖尿病糖尿病肾病视黄醇结合蛋白4 肾小球滤过率

分类号 R587.24 [医药卫生—内分泌]

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