术前放疗在肢体滑膜肉瘤保肢治疗中的临床应用

Preoperative radiotherapy in limb synovial sarcoma limb-salvage in clinical application

目的探讨术前放疗在肢体滑膜肉瘤保肢手术中的临床效果。方法收集2005年6月-2008年5月在我院行保肢手术治疗的92例肢体滑膜肉瘤患者的临床资料,比较2组术前、术后放疗效果及复发率。结果 (1)观察组手术时间、术中出血量显著低于对照组(P<0.05),引流管放置时间、术后引流量、切口愈合时间显著高于对照组(P<0.05),两组患者切口感染率差异无统计学意义(P>0.05)。(2)观察组复发率、转移率显著低于对照组,保肢率、5年生存率显著高于对照组(P<0.05)。结论术前放疗远期疗效优于术后放疗。

Objective To explore the preoperative radiotherapy in limb synovial sarcoma limb-salvage surgery clinical effect. Methods From June 2005 to May 2008 in our hospital limb salvage treatment the clinical datas of 92 patients with limb synovial sarcoma,compare 2 groups befor surgery postoperative radiotherapy effect and recurrence rate. Results （1）Observation group op-eration time,intraoperative blood loss was significantly lower than the control group （P〈0.05）,drainage tube placement time,flow rate and postoperative incision healing healing time was significantly higher than the control group （P〈0.05）,there was no statisti-cally significant difference incision infection rate in both groups （P〉0.05）.（2）Observation group of metastasis and recurrence rate was significantly lower than the control group,the limb salvage rate,the five-year survival rate is significantly higher than the con-trol group （P〈0.05）. Conclusion The long-term curative effect of preoperative radiotherapy is better than that of postoperative ra-diotherapy.