盐酸萘替芬溶液剂的含量测定

Determination of naftifen solution by UV spectrophotometry

目的 :建立紫外分光光度法测定盐酸萘替芬溶液剂含量的方法。方法 :采用多台紫外分光光度仪 ,配制盐酸萘替芬高低两种浓度的溶液 ,进行盐酸萘替芬吸收系数 (E1%1cm)测定 ,并建立样品的含量测定方法。结果 :空白基质在测定波长处对样品测定没有干扰 ,盐酸萘替芬的线性范围为 1.6～ 16 μg·ml-1,r=1.0 0 0 0 ,日内偏差为 0 .2 0 % (n =6 ) ,平均回收率为 10 0 .4% ,RSD =0 .39% (n =6 )。结论 :方法灵敏简便 。

OBJECTIVE:To determine the content of naftifen solution by UV spectrophotometry.METHODS:The E 1% 1cm of naftifen was determined using two concentration of naftifen solutions with five UV spectrophotometors.RESULTS:The excipients had no interference.The calibration curve was linear in 1.6 ～ 16 μg·ml -1 , r = 1.000 0 .Coefficient of inter day variation was 0.20 %( n =6).The recovery rate was 100.4 %( RSD = 0.39 %).The average content of three batches of samples was 97.90 % of labelled amount.CONCLUSIONS:The method was simple and accurate. [