钝顶螺旋藻多糖对急性白血病病人NK细胞的作用

STUDY ON EFFECT OF SPIRULINA PLATENSIS POLYSACCH-ARIDE ON NK CELLS FROM ACUTE LEUKEMIA PATIENT IN VITRO

目的 探讨螺旋藻多糖 ( SPP)对白血病患者免疫功能的作用 ,观察了 SPP对正常人及急性白血病患者外周血 NK细胞的影响。结果 SPP可提高不同病期白血病患者 NK细胞活性 ,但不影响正常人 NK细胞活性 ,毒性试验表明 SPP对白血病细胞无毒性作用。结论 SPP作为生物反应调节剂用于白血病治疗可提高 NK细胞活性 ,值得进一步研究、开发、应用。

AIM:The Effects of Spirulina Platensis Polysaccharide (SPP)on peripheral NK cell from healthy persons and acute leukemia patients were studied.METHODS:The activities of NK cell on target cell K 562 was measured with MTT method.RESULTS:The results showed that SPP could argument the NK cell activity from varies peroid cases with acute leukemia.SPP had no activity on NK cell from normal person.Cytotoxicity did not present when the peripheral blood mononuclear cell were co incubated with SPP.CONCLUSION:These results suggested that SPP could be exploited and utilized as an approach of biological responsive modifier therapy in the treatment of acute leukemia.