我院2010-2012年门诊药房麻醉药品应用分析

Analysis of the Utilization of Narcotic Drug in Outpatient Pharmacy of Our Hospital from 2010 to 2012

目的:旨在给临床医师使用麻醉药品提供参考。方法:收集某院2010-2012年共3 847张麻醉药品处方,以世界卫生组织(WHO)推荐的限定日剂量(DDD)、用药频度(DDDs)、药物利用指数(DUI)为指标进行分析和评价。结果:共涉及麻醉药品8种,剂型3种(注射剂4种,片剂3种,贴剂1种)。3年间麻醉药品消耗金额呈递增趋势,2010、2011、2012年消耗金额分别为20 133.20、86 136.33、171 872.86元。盐酸吗啡缓释片的DDDs最高,盐酸羟考酮缓释片和芬太尼透皮贴剂的DUI较高。结论:该院盐酸哌替啶注射液已不再应用于癌症镇痛,仅用于内脏绞痛、创伤、术后镇痛;盐酸吗啡缓释片、盐酸羟考酮缓释片、芬太尼透皮贴为治疗癌痛使用的主要药物;盐酸吗啡注射液、盐酸布桂嗪注射液、枸橼酸芬太尼注射液则应用较少,符合WHO的癌痛治疗原则。

OBJECTIVE： To provide reference for the clinical use of narcotic drugs by clinical physicians. METHODS： 3 847 narcotic prescriptions in a hospital from 2010 to 2012 were collected and analyzed according to DDD, DDDs and DUI recommend by WHO. RESULTS： 8 varieties and 3 dosage forms of narcotic drugs were involved, including 4 injections, 3 tablets, and 1 transdermal patch. The consumption sum of narcotic drugs showed a gradual increasing tendency during last 3 years; the total consumption sum of narcotic drugs from 2010 to 2012 were 20 133.20 yuan, 86 136.33 yuan and 171 872.86 yuan, respectively. DDDs of Morphine hydrochloride sustained-release tablets were the highest, and Oxycodone hydrochloride sustained-release tablets and Fentanyl transdermal had a greater DUI than others. CONCLUSIONS： Pethidine hydrochloride injection is not used to control the cancer pain anymore; it is just be used for viscera angina, trauma and postoperative analgesia. Morphine hydrochloride sustained-release tablets, Oxycodone hydrochloride sustained-release tablets and Fentanyl transdermal patch are the main drugs for cancer pain, but not the Morphine hydrochloride injection, Bucinnazine hydrochloride injection and Fentanyl citrate injection. It is in line with the principle of cancer treatment recommended by WHO.