555例药物引发双硫仑样反应的文献分析

Literature Analysis of 555 Cases of Drug-induced Disulfiram-like Reaction

目的:了解临床引发双硫仑样反应的药物种类及其特点。方法:对中国知网2011年1月-2013年1月收录的医药学期刊中有关药物致双硫仑样反应的病例进行分析统计,包括药物品种、临床表现、使用含醇制品的种类、剂量及时间。结果:引发双硫仑样反应药物有22种,其中主要为头孢菌素类药物,占到91.17%;主要临床表现为颜面潮红、心悸、胸闷;服药前、服药期间及停药后接触含醇制品均可引发双硫仑样反应,用药后5 min^1 h发生率最高。结论:医务工作者和患者应高度重视双硫仑样反应。

OBJECTIVE： To understand the drug types and characteristics of disulfiram-like reaction. METHODS： The literatures of drugs-induced disulfiram-like reaction included in CNKI during Jan. 2011-Jan. 2013 were analyzed statistically in terms of drug types, clinical manifestation, the type, dosage and time of alcohol products. RESULTS ： There were 23 kinds of drugs which induced sulfiram-like reaction, mainly induced by cephalosporin drugs, accounting for 91.17 %. Major clinical manifestations included facial flushing, palpitations and chest tightness. The alcohol products could result in sulfiram-like reaction before medication, during medication and after discontinuation. The incidence of sulfiram-like reaction was the highest in 5 min-1 h after medication. CONCLUSIONS ： The medical workers and patients should pay high attention to the disulfiram-like reaction.